Rel homology region

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August undefined, 2024

Webbinding (Rel homology) region of NFAT family proteins (top). A wide-range genomic view of NFATc1 and NFATc2 genes suggests that these genes were generated by chromosomal gene duplication (bottom). (B) Loss-of-function analyses of NFATc2 in osteoclast differentiation. Microradiographic analysis of femur derived from NFATc2 / mice at The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and pr…

NF-κB, IκB, and IKK: Integral Components of Immune System

WebJun 6, 2003 · Using bioinformatics tools, we identified a Rel homology region (RHR) within CSL that was used as a guide to determine the minimal protein requirements for ternary complex formation. The RHR of CSL contains both the N- and C-terminal beta-sheet domains (RHR-n and RHR-c) of typical Rel transcription factors, as judged by circular dichroism … WebJan 26, 1995 · The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region … trinity youtube kids

NF-kB pathway overview Abcam

WebFeb 13, 2024 · The vertebrate p53 homologs generally share low sequence homology in regions other than their DNA-binding domains (Ou et al., 2007; Lu & Abrams, 2006). In line with ... in these short sequences is difficult to detect. However, the conservation of the REL motif in some interfaces, coupled with the structural ... WebThe rel family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the rel domain. The rel family comprises … WebRel Homology Domain. 92,93 The RHD is also known as the DNA-binding domain (DBD) of NFAT proteins, which shows a structural similarity to the DBD of nuclear factor-κB (NF … trinity yucaipa group home

NFAT5, a constitutively nuclear NFAT protein that does not

Structure of the NF-κB p50 homodimer bound to DNA Nature

WebDec 30, 2024 · Passionate about developing regional and global tech innovation ecosystems and champion of the Global Innovation … WebThe Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, [2] including both NF-κB and NFAT, among others. Some of these transcription factors appear to form multi-protein DNA -bound complexes. [3] … trinity youtube channelWebJul 30, 2015 · The mammalian NF-κB family consists of five members: p65/RelA, RelB, c-Rel, p50 and p52, which share structural homology in their N termini with the retroviral oncoprotein v-Rel. via this rel homology region (RHR) they form stable homo- … trinity yucaipa residential treatment center

"WebFeb 1, 1996 · The defining characteristic of Rel proteins is a stretch of roughly 300 amino acids called the Rel homology region (RHR) or Rel homology domain (RHD), within which … " - Rel homology region

Rel homology region

Structural requirements for assembly of the CSL.intracellular …

WebJan 6, 2024 · The Rel homology region (RHR) is an evolutionarily conserved N-terminal DNA-binding region present in two major paralogous families of animal transcription factors … WebFeb 1, 1994 · Europe PMC is an archive of life sciences journal literature.

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WebThe novel molecule, designated NFATx, exhibits in its middle a region very similar to the Rel homology domain in NFATc and NFATp. The amino-terminal region of NFATx also shows significant similarities to corresponding sequences in NFATc and NFATp and contains three copies of a conspicuous 17-residue motif of unknown function. WebJan 26, 1995 · The structure of a large fragment of the p50 subunit of the human transcription factor NF-κB, bound as a homodimer to DNA, reveals that the Rel-homology …

WebJun 22, 1999 · The Rel homology region of NFAT5 showed 41–45% identity with NFAT1–4 and 15–17% identity with p50 NF-κB in pairwise comparisons (Fig. 2 a and b), indicating … WebFeb 24, 1995 · Within this region, there is a span of ∼300 amino acids that shows a low level of sequence identity with the Rel homology region (RHR) previously recognized in Rel …

WebNuclear factor of activated T cells (NFAT) and recombination signal binding protein (RBP) belong to the family of Rel homology region (RHR) transcription factors which regulate … WebRel Homology Region (RHR) Class I p50 Class II p65 c-Rel ReIB C kB DNA N N N N C C p50 RHR p50 D256 N200 F213 p65 GGG5´ Y269 R56 R58 H66 Y59 p65 RHR C p52 A CD F E B NTD DimD LG 433 NTD DimD L 447 NTD DimD TADL 551 N NTD DimD TAD 619 Amino-terminal domain Dimerization domain C Linker L LZ NTD DimD L TAD 557 G Figure2. The …

WebThis gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes.

WebOct 19, 2024 · 10.3.1 Rel Homology Region (RHR) Structure. The first glimpse into the structural details of the NF-κB pathway was afforded by two separate X-ray crystallographic analyses of the NF-κB p50:p50 homodimer RHR in complex with κB DNA [20, 50]. trinity yukon baptist churchWebMar 1, 1994 · Within the Rel homology region of NF-kappa B p50 (also known as KBF1), two amino acid residues were identified by photocrosslinking to adjacent bases in a beta-interferon regulatory element. trinity yumaWebAll these proteins share a highly conserved 300 aa Rel homology region (RHR), which is responsible for dimer-ization, DNA-binding and interaction with the inhibitory IκB proteins. trinity yunWebThe sequence of this region of NFATp shows a low degree of similarity to the Rel homology region. One specific short sequence in NFATp (RAHYETEG), located near the NH2 terminus of the DNA-binding domain, … trinity yucaipaWebAug 31, 2003 · The crystal structure of the NFAT1 Rel homology region (RHR) bound to a pseudo-palindromic DNA site reveals an asymmetric dimer interaction between the RHR-C … trinity yukon facebookWebJan 9, 2024 · Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA. This study provides first evidence that the USP domain of USP48 is important for the physical association with substrate proteins, and a suitable target for small … trinity yvonne-eileen richardson obituaryWebNov 23, 2024 · The N-termini of all family members share a high degree of sequence homology known as the Rel Homology Region ... Kelly, K., and Siebenlist, U. (1990). Cloning of a Mitogen-Inducible Gene Encoding a κB DNA-Binding Protein With Homology to the Rel Oncogene and to Cell-Cycle Motifs. Nature 348, 76–80. doi:10.1038/348076a0. PubMed ... trinity yvonne-eileen richardson