WebOPA1 is a dominantly inherited optic neuropathy occurring in 1 in 50,000 individuals that features progressive loss in visual acuity leading, in many cases, to legal blindness. … WebOPA1 is a dynamin-related GTPase that controls mitochondrial dynamics, cristae integrity, energetics and mtDNA maintenance. The exceptional complexity of this protein is …
Characterization of OPA1 isoforms isolated from mouse tissues
WebIt is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Web13 de abr. de 2024 · Objective Intriguingly, hyperinsulinemia, and hyperglycemia can predispose insulin resistance, obesity, and type 2 diabetes, leading to metabolic disturbances. Conversely, physical exercise stimulates skeletal muscle glucose uptake, improving whole-body glucose homeostasis. Therefore, we investigated the impact of … flm cb-32f ball head
Identification of new OPA1 cleavage site reveals that short …
Web14 de abr. de 2008 · In order to correlate the individual OPA1 proteins bands that migrate with apparent molecular weights of 80–100 kDa with specific OPA1 isoforms, we immunoprecipitated OPA1 protein from purified mitochondria of mouse brain, heart, liver, and kidney and performed peptide mining. WebProduct Details Product Specific Information In Western blot, this antibody detects a single ~180 kDa protein representing NR2A in rat brain homogenate. It shows no cross-reactivity with NR2B. Reconstitute with 50 µL of PBS. Target Information N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. Web26 de nov. de 2024 · Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial … great harvest bread company clackamas