On the front rho
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On the front rho
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Web21 de jan. de 2009 · This has led to the suggestion that localized Rac activation at the front and Rho activation at the rear, promote migration. While this is a far too simplistic view of the process (for example, active Rho can also be detected at the front), Rho and/or Rac are essential for the migration of many different cell types [ 79 , 80 ]. Web15 de set. de 2005 · Among Rho GTPases, Rho plays a major role in actin assembly and generating the force on the ECM, and Rac but not Cdc42 also contributes to force exerted on ECM [Zhong et al., 1998; Ridley, 2001; Li et al., 2003]. While Rac modulates the actin polymerization and force generation in the front, Rho may be involved in the contraction …
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