Gsdme chemotherapy
WebChemotherapy-induced amenorrhea (CIA) is the temporary or permanent loss of menses experienced by premenopausal women undergoing chemotherapy treatment for can 掌桥科研 一站式科研服务平台 WebApr 24, 2024 · GSDME cleavage by the pro-apoptotic caspases determines whether chemotherapy drug treatments induce apoptosis or pyroptosis, however, its regulation mechanisms are not clear. In this study, we...
Gsdme chemotherapy
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WebOct 1, 2024 · The standard chemotherapy for SCLC consists of platinum-based chemotherapy combined with the topoisomerase II inhibitor etoposide, which was defined decades ago ( 3 ). A remarkable response to the chemotherapy is followed almost invariably by the development of resistant disease. WebAug 8, 2024 · Caspase‐3‐mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil.
WebBIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis Adjuvant chemotherapy in combination with surgery is expected to be a curative strategy for gastric cancer. However, drug resistance remains an obstacle in effective chemotherapy. WebThe expression level of GSDME in tissue samples were examined by immunohistochemistry. Findings: We found that the combination of BI2536 and DDP was synergistic in ESCC cells, which induced pyroptosis in ESCC cells at low doses. Mechanistic studies revealed that BI2536 significantly induced DNA damage and impaired the DNA …
WebMar 3, 2024 · In this study, we aimed to explore the role of GSDME methylation in the sensitivity of chemotherapy for breast cancer. Methods Here, we identified breast … WebApr 24, 2024 · GSDME cleavage by the pro-apoptotic caspases determines whether chemotherapy drug treatments induce apoptosis or pyroptosis, however, its regulation …
WebGSDME may be an important prognostic indicator of survival in patients with lung cancer- read the full article online ... 2013 and December 30, 2014. None of the patients received radiotherapy or chemotherapy before surgery for sample collection. Further, the presence or absence of lymph nodes and distant metastasis of lung cancer, the survival ...
WebFurthermore, caspase-3/GSDME-mediated pyroptosis is involved in chemotherapy-induced tissue damage, providing a new target for the treatment of cancer. 58 A recent study revealed that cleavage of GSDME by caspase-1/3/7 is the only pathway that induces pyroptosis in teleosts. 50 chris aiello perry hall middle schoolWeb15 hours ago · GSDMD and GSDME are more ubiquitously expressed, with notably high expression in immune cells. Humans encode six GSDMs: GSDMA, ... In wound-healing models associated with IBD, treatment with the chemotherapy and immunosuppressant drug methotrexate induced proliferation in wild-type GSDMB epithelial cells but not in … genshin a journey through pages mapWebApr 6, 2024 · Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells and trigger anti-tumor immunity, … genshin akasha pulses the kalpa flame risesWebUnlike numerous gasdermin family proteins in mammals, only gasdermin E (GSDME) has been identified in fish. GSDME in fish can be cleaved by caspase-a/-b to release its NT domain and induce pyroptosis. ... recent studies have found that some chemo-therapeutics can cleave GSDME via caspase-3 to induce the pyroptosis of tumor cells. 31 Caspase-3 ... genshin akasha system websiteWebYu, X., & He, S. (2024). GSDME as an executioner of chemotherapy-induced cell death. Science China Life Sciences, 60(11), 1291–1294. doi:10.1007/s11427-017-9142-2 chrisa hotel thassosWebMay 24, 2024 · Gasdermin (GSDM) is a family of pore-forming proteins that, after cleavage by caspase (CASP), induce a type of programmed necrotic cell death called pyroptosis. Gasdermin E (GSDME) is the only... chris aielloWebNov 16, 2024 · The cleavage of GSDME after treatment of cancer with chemotherapy agents provides a cross-talk between the pro-inflammatory process of pyroptosis and the anti-inflammatory process of apoptosis (Zheng and Li, 2024). Thus, GSDME may be regarded as a “molecular switch”, in that its cleavage status determines whether cells … genshin akiramod