Ebf1 activator
WebOct 10, 2012 · Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med 2011; 208 : 1135–1149. Article CAS PubMed PubMed Central Google Scholar WebMoreover, the activation of the Ebf1α promoter by EBF1H240A was reduced relative to the activation by EBF1wt (Fig. 7J). Thus, efficient EBF1 binding at the −5.4-kb site of the distal Ebf1 α promoter and autoregulation by EBF1 both appear to …
Ebf1 activator
Did you know?
WebThe T26-818 monoclonal antibody specifically binds to Early B-cell Factor 1 (Ebf1) which is also known as, Transcription factor COE1, or Olfactory 1 (Olf-1/Olf1). Ebf1 belongs to the Collier/Olf1/EBF (COE) family of transcription factors. It is involved in early B cell development in the mouse and human. WebNov 15, 2024 · Unlike the responses of EBF1 to AHR activation , all three transcription factors exhibited modest changes that occurred only in the late stage of the 28-d culture period . Hence, we hypothesize that AHR can exert direct transcriptional regulation of EBF1. It is established that AHR is a ligand-activated transcription factor, which regulates ...
WebThe results we obtained from this study indicated that the EBF1 gene suppresses the activation of the MAPK axis, thereby promoting both the proliferation and migration of bone marrow CD34+ cells as well as inhibiting the associating apoptosis. The effects of the EBF1 gene are likely to present a new therapeutic target in preventing the ... WebMay 10, 2004 · Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes (PubMed:14630787). Interacts with CCR4-NOT component CNOT3 (PubMed: 14630787 ). 2 publications (Microbial infection) Interacts with Epstein-barr virus protein EBNA2. 1 publication
WebJan 15, 2024 · PAX5 and EBF1 work synergistically to regulate genes that are involved in B lymphocyte differentiation. We used the KIS-1 diffuse large B cell lymphoma cell line, … WebExpression of core transcription factors regulating early B cell development, such as E2A, Ebf1, and Pax5, was reduced in B cell precursors lacking Runx1. We detected binding of Runx1-Cbfβ complexes to the Ebf1 proximal promoter, and these Runx-binding motifs were essential to drive reporter gene expression.
WebEBF1 has been shown to bind to the Pax5 promoter and induce Pax5 expression (Cobaleda et al., 2007). Interestingly, although EBF1 is expressed earlier than PAX5, PAX5 binds the Ebf1 promoter and is required to maintain normal levels of Ebf1 expression (Cobaleda et al., 2007; Roessler et al., 2007). Thus, PAX5 and EBF1 act as part of a self ...
WebApr 4, 2012 · Nonredundant functions of EBF1 and Pax5 in early B cell development. (A) Ebf1 ihCd2/+ (blue) and WT (black line) mice were analyzed by flow cytometry for … doesn\\u0027t this guitar sound so goodWebJun 30, 2013 · The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage program and irreversible loss of alternative lineage potential (commitment), respectively. Here we ... facebook marketplace myrtle beachWebThis article is Driver61’s recommended FFB setup guide in Assetto Corsa Competizione on both Console and PC. Whether you are a new player to the popular SIM franchise or an … facebook marketplace mustangWebMar 21, 2024 · Go to complete Gene record for EBF1; Go to Variation Viewer for EBF1 variants; Summary. Predicted to enable DNA-binding transcription activator activity, … doesn\\u0027t think before actingWebDec 1, 1999 · Furthermore, while Ebf1 has previously only been shown to function as a transcriptional activator, in B cells and in olfactory neurons (Hagman et al., 1993, 1995; Wang and Reed, 1993; Wang et al., 1997), the present work points to an involvement of Ebf1 in the activation of two mantle markers as well as the downregulation of several … facebook marketplace nampa idWebMay 24, 2024 · Hello, I Really need some help. Posted about my SAB listing a few weeks ago about not showing up in search only when you entered the exact name. I pretty … doesn\u0027t tinted moisturizer mess up primerWebMar 15, 2016 · The EBF1-dependent activation of Cd79a has been shown to correlate with a loss of DNA methylation (Maier et al., 2004). To investigate the association of EBF1 occupancy and DNA demethylation on a genome-wide scale, we performed bisulfite sequencing of DNA in Ebf1 −/− pre-pro-B cells transduced with empty vector, EBF1wt, or … doesn\\u0027t use authentication